Coumadin is used for treating and preventing harmful clots that may occur in the veins (venous thrombosis), in the lungs (pulmonary embolism), with a type of abnormal heartbeat (atrial fibrillation), or following a heart valve replacement.
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What is a substitute for coumadin ? Is there any alternative, in your opinion, when it comes to treating patients who had HIV, with the drug AZT? Why does the "A/B" study not show an apparent which is better coumadin or warfarin improvement in AZT/Coumadin-treated patients? Have you found any possible reasons for this difference? Why do you believe that the A/B combination may help more than AZT only if it is combined with another drug? Could it be that this patient is actually infected with HTLV-1 and has been given a false impression of success with Coumadin alone? Thank you for your time and assistance in answering these questions on behalf of the patient. Your response has been received. Please Cost pentasa generic reply to: Dr. William P. Heilbronn III The National Institutes of Health, Health Information Services, CDC 301 E. Grandville Rm. B-250, MSC 5663 Chicago, IL 60653 Thank you for the opportunity to answer these questions. We understand your need for confidentiality in this process, as there may be an identifiable health risk involved. Please advise the patient in writing so any identifiable information can be redacted from any reports you submit to the CDC. As the medical director of Division Antiviral Medicine at CDC, I am providing you an interview with Dr. Charles A Nelson, M.D., M.P.H. (CDC/National Institute of Allergy and Infectious Diseases), who is in Washington, DC, to provide an update on the A/B Group Trial results. was designed in part because the A/B drug combination approach had failed to show any apparent advantage over Coumadin only. This trial represents a new approach to HIV treatment. The trial is intended to assess the clinical efficacy of multiple antiretroviral agents that may be combined in a single oral dose to lower the risk of serious side effects. The primary endpoint of trial is the reduction in HIV-related deaths (HIV-related occur when people acquire a fatal illness from sexually transmitted disease). There are 5 arms with each arm consisting of 3 to 7 patients. The A and B groups received 3 to 4 weeks of treatment with either AZT [Coumadin-based drugs], or the combination of AZT with 2 3 other drugs in the arm [AZT, AZT + Crixivan, and Zidovudine]. The objective in all 3 arm study is to compare the number of deaths due to AIDS-related complications using methods that can be easily ascertained. Thus we do not expect all deaths to be associated with AIDS related complications in the two groups. These results show the combined drug treatment did not significantly reduce the number of patients that died in any Arm. The study of AZT versus Coumadin-based drugs, which appears to be most similar the A/B approach, showed a non-significant significant benefit in patients with an HIV-associated disease or those that died from AIDS-related complications. While it was expected in the setting of a large enough trial that one would see a large benefit that was consistent in this setting, not anticipated. We believe the study of AZT versus Coumadin-based drugs was significantly compromised by lack of power for the study and failure to perform a post-hoc analysis of the data. Given those issues, we believe it is imperative that further studies be undertaken can evaluate the effect of AZT in these larger sample sizes. We understand that your organization continues to investigate the question of why Coumadin treatment did not improve the lives of this patient. There Verapamilo generico precio is evidence suggesting that it may be related to a genetic condition known as Koplik's syndrome that affects approximately 1% of the Caucasian population. Dr. Nelson believes this treatment is not an option. He says that in general if a patient with KS is on a high dose of AZT, then this may increase the risk of a reaction, but is not likely explanation. He emphasizes this patient did not have that level of infection and was not on an all-ergenic regimen with AZT. The trial is expected to end in June Pentasa enema precio mexico or July 2005. Dr. Nelson says that he hopes CDC/NIH will make the results publicly available soon for peer review and evaluation, but says that he is not sure how this information will be conveyed since this is a very sensitive issue. He also stresses his message to the patient that information will not jeopardized as long he remains available to him. urges the patient keep information confidential as he will not want it to be used advocate any action, but advises he should not send the information to any potential employers. He also says this patient has an outstanding physician and he hopes this experience has taught the physician that they must take the same great care to protect and preserve a patient's.
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